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Updated: Jul 10, 2026

DNA-affinity-purified Chip (DAP-chip) Method to Determine Gene Targets for Bacterial Two component Regulatory Systems
Published on: July 21, 2014
Recognition and integration of multiple environmental signals by the bacterial sensor kinase PhoQ
John S Gunn1, Susan M Richards
1Center for Microbial Interface Biology, The Ohio State University, Columbus, OH 43210, USA. gunn.43@osu.edu
Abstract:
Two-component regulatory systems are commonly used by bacteria to sense and respond to their environment. In Molecular Cell, Prost et al. describe how low pH activates the Salmonella PhoQ sensor kinase, building on their previous demonstration that the PhoQ periplasmic domain senses magnesium and antimicrobial peptides. These findings are likely to be broadly applicable for understanding how bacteria recognize and transduce the multiple signals characteristic of their complex extracellular environments.
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