Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bacillus subtilis: a shocking message from a probiotic.

Paul Williams1

  • 1Institute of Infection, Immunity and Inflammation, Centre for Biomolecular Sciences, University of Nottingham, Nottingham NG7 2RD, UK. paul.williams@nottingham.ac.uk

Cell Host & Microbe
|November 17, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A mixed-methods analysis of the implementation of a new community long-COVID service during the 2020 pandemic: Learning from practice.

PloS one·2026
Same author

Assessing the association of physical distancing to avoid COVID-19 with health-related quality of life in immunocompromised adults: results from the cross-sectional observational EAGLE study.

BMJ public health·2026
Same author

Assessing the association of physical distancing to avoid COVID-19 with health-related quality of life in immunocompromised adolescents: results from the cross-sectional observational EAGLE study.

Frontiers in pediatrics·2026
Same author

Prospective evaluation of therapeutic target attainment with a beta-lactam dosing nomogram in critically ill adult patients.

International journal of antimicrobial agents·2026
Same author

Age and symptom severity as predictors of outcomes following shockwave therapy in Achilles tendinopathy : a single-centre observational study.

The bone & joint journal·2026
Same author

Fragile research systems, brain drain, and predatory publishing in under-resourced countries.

microLife·2026
Same journal

Gut commensal Bacteroides-derived pantothenic acid alleviates metabolic syndrome.

Cell host & microbe·2026
Same journal

Predicting antimicrobial resistance for precision medicine.

Cell host & microbe·2026
Same journal

Meta-analysis reveals microbiome signatures for colorectal cancer that are universal across age groups and sequencing methods.

Cell host & microbe·2026
Same journal

Single-cell detection and quantification of the microbiota by MicFLY.

Cell host & microbe·2026
Same journal

Suppression of host salicylic acid defense by a phloem-colonizing pathogen effector in citrus Huanglongbing.

Cell host & microbe·2026
Same journal

CBASS limits bacteriophage production while maintaining cell viability in Pseudomonas aeruginosa.

Cell host & microbe·2026
See all related articles

Bacillus subtilis uses a signal molecule to protect the gut. This molecule enters cells via OCTN2, boosting heat shock protein Hsp27 to shield intestinal cells from damage.

Area of Science:

  • Microbiology
  • Immunology
  • Cell Biology

Background:

  • Probiotics, including Bacillus subtilis, are known to confer health benefits, but the precise mechanisms remain unclear.
  • Understanding how these beneficial bacteria interact with the host at a molecular level is crucial for harnessing their therapeutic potential.

Discussion:

  • This study elucidates a novel mechanism by which Bacillus subtilis protects the intestinal barrier.
  • The findings highlight the role of bacterial quorum-sensing molecules in host-microbe interactions.

Key Insights:

  • Bacillus subtilis competence- and sporulation-stimulating factor (CSF) is internalized by intestinal cells through the oligopeptide transporter OCTN2.
  • Internalized CSF induces the expression of heat shock protein Hsp27.
  • Hsp27 protects intestinal cells from oxidant-mediated damage and maintains barrier function.

Related Experiment Videos

Outlook:

  • This research opens new avenues for developing probiotic-based therapies targeting intestinal health.
  • Further investigation into OCTN2-mediated signaling could reveal broader applications in managing inflammatory conditions.