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Updated: Jul 10, 2026

Generating Genetically Modified Plasmodium berghei Sporozoites
Published on: May 5, 2023
Transgenic parasites: improving our understanding of innate immunity to malaria
1Laboratory of Malaria and Vector Research, NIAID/NIH, Bethesda, MD 20892, USA. rfairhurst@niaid.nih.gov
Abstract:
Clinical immunity to Plasmodium falciparum malaria takes years to develop and is never complete. One explanation for these observations is that antigenic variation enables malaria parasites to evade humoral immunity; another is that P. falciparum induces immune dysregulation, which inhibits the development of protective cellular immunity. Research described by D'Ombrain et al. in this Cell Host & Microbe issue probes how the parasite's main virulence factor PfEMP-1 might significantly alter human innate immune responses.
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