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Updated: Jul 10, 2026

Vaccinia Reporter Viruses for Quantifying Viral Function at All Stages of Gene Expression
Published on: May 15, 2014
Vaccinia, Inc.--probing the functional substructure of poxviral replication factories
1Department of Molecular Genetics and Microbiology, University of Florida, P.O. Box 100266, Gainesville, FL 31610, USA. condit@mgm.ufl.edu
Abstract:
Poxviruses replicate in viral factories in the host cell cytoplasm. In this issue of Cell Host & Microbe, Katsafanas and Moss identify discrete poxviral factory subdomains that contain locally synthesized virus proteins and specifically imported host proteins, and within which viral transcription and translation take place simultaneously. These factories thus comprise a highly structured virus organelle that isolates and coordinates late viral replication events, facilitating competition for cellular resources.
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