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Automated Lipid Bilayer Membrane Formation Using a Polydimethylsiloxane Thin Film
Published on: July 10, 2016
Phosphatidylcholine embedded micellar systems: enhanced permeability through rat skin
Aviram Spernath1, Abraham Aserin, Amnon C Sintov
1Casali Institute of Applied Chemistry, The Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
Journal of Colloid and Interface Science
|November 17, 2007
Summary
This study shows that micellar systems with phosphatidylcholine (PC) enhance sodium diclofenac (DFC) transdermal delivery. These systems improve drug penetration through the skin, offering better bioavailability.
Area of Science:
- Physical Chemistry
- Materials Science
- Pharmaceutical Sciences
Background:
- Micellar and microemulsion systems offer high drug solubilization and bioavailability.
- Propylene glycol (PG) and nonionic surfactants are key components in drug delivery systems.
- Phosphatidylcholine (PC) acts as a transmembrane transport enhancer.
Purpose of the Study:
- To develop fully dilutable micellar and microemulsion systems for sodium diclofenac (DFC) delivery.
- To investigate the phase transitions and solubilization capacity (SC) of these systems.
- To evaluate the transdermal penetration of DFC and the role of PC.
Main Methods:
- Preparation of mixtures of PG, nonionic surfactants, DFC, and PC.
- Characterization of phase transitions (reverse micelles, bicontinuous mesophase, O/W microstructures).
- In vitro transdermal penetration studies using rat skin.
Main Results:
- Maximum DFC solubilization capacity (SC) was achieved at pH 7.
- Transdermal penetration correlated with SC, water content, PC, oil phase, and ethanol.
- O/W microstructures and bicontinuous mesophases showed higher DFC skin penetration than W/O droplets.
- PC significantly increased penetration flux and, with HECO40, improved permeation rate and reduced lag-time.
Conclusions:
- Micellar and microemulsion systems containing PC are effective for DFC transdermal delivery.
- System composition and microstructure influence drug penetration efficacy.
- PC incorporation enhances drug permeation across the skin.
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