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In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction

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Altered dendritic cell function in normal pregnancy.

V Bachy¹, D J Williams, M A A Ibrahim

¹Department of Clinical Immunology, King's College Hospital, Denmark Hill, London SE5 9RS, UK.

Journal of Reproductive Immunology

|November 17, 2007

Summary

This summary is machine-generated.

Pregnancy modifies dendritic cells (DCs) to promote immune tolerance. Pregnant women show reduced DC maturation and altered cytokine production, favoring type 2 T helper cell responses to support gestation.

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Area of Science:

Immunology
Reproductive immunology

Background:

Maternal immune system undergoes significant adaptations during pregnancy to tolerate the semi-allogeneic fetus.
Dendritic cells (DCs) are critical regulators of immune balance, influencing T helper cell differentiation and immune tolerance.

Purpose of the Study:

To investigate modifications in myeloid dendritic cells during pregnancy.
To determine if these changes favor type 2 T helper cell responses, crucial for maintaining gestation.

Main Methods:

Analysis of circulating myeloid dendritic cells (CD86, HLA-DR expression) in pregnant versus non-pregnant women.
Assessment of monocyte-derived dendritic cell (moDC) differentiation and maturation markers (CD80, CD86, HLA-DR).
Evaluation of cytokine secretion (IL-10, IL-12p70) by moDCs in response to inflammatory stimuli.

Main Results:

Pregnant women exhibited lower proportions of circulating myeloid DCs expressing CD86 and HLA-DR in the third trimester.
Monocytes from pregnant women differentiated into less mature DCs with reduced CD80, CD86, and HLA-DR expression.
Pregnant women's moDCs secreted less IL-12p70 and more IL-10, with a stronger CD86 than CD80 upregulation upon stimulation.

Conclusions:

The dendritic cell system is altered during pregnancy to promote immune tolerance.
These modifications favor type 2 T helper cell responses, contributing to successful gestation and fetal tolerance.