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Supercritical carbon dioxide processing of active pharmaceutical ingredients for polymorphic control and for complex
Kunikazu Moribe1, Yuichi Tozuka, Keiji Yamamoto
1Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.
Advanced Drug Delivery Reviews
|November 17, 2007
Summary
Supercritical carbon dioxide (scCO2) processing offers precise control over active pharmaceutical ingredient particle characteristics. This technique is valuable for polymorphic control and complexation, enhancing drug solubility and formulation properties.
Area of Science:
- Pharmaceutical Science
- Materials Science
- Chemical Engineering
Background:
- Supercritical fluid techniques are established for extraction, separation, and crystallization.
- Supercritical carbon dioxide (scCO2) is utilized in pharmaceutics for micronization, polymorphic control, and preparing solid dispersions and complexes.
- Optimizing particle design is crucial for active pharmaceutical ingredients (APIs) to achieve desired physicochemical properties in solid dosage forms.
Purpose of the Study:
- To review the application of supercritical carbon dioxide (scCO2) processing for controlling API polymorphism.
- To explore the complexation behavior of APIs using scCO2.
- To highlight the role of scCO2 in enhancing solubility for poorly water-soluble drugs.
Main Methods:
- Focus on supercritical carbon dioxide (scCO2) processing.
- Review of techniques for particle design, including micronization and polymorphic control.
- Analysis of solid dispersion and complexation preparation methods.
Main Results:
- scCO2 processing enables precise control over particle size, shape, crystal structure, and morphology.
- Solid dispersion and complexation using scCO2 are effective for improving the solubility of poorly water-soluble drugs.
- scCO2 processing facilitates targeted polymorphic control of APIs.
Conclusions:
- Supercritical carbon dioxide (scCO2) is a versatile tool for API particle design and formulation development.
- scCO2 processing is key for achieving desired physicochemical properties and enhancing drug solubility.
- This review underscores the significance of scCO2 in pharmaceutical particle engineering for improved drug delivery.
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