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Related Experiment Video

Updated: Jul 10, 2026

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

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Quantification of myocardial perfusion using dynamic 64-detector computed tomography.

Richard T George¹, Michael Jerosch-Herold, Caterina Silva

¹Department of Medicine, Division of Cardiology, Image Guided Cardiotherapy Laboratory, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

Investigative Radiology

|November 17, 2007

Summary

Dynamic 64-slice multidetector computed tomography (d-MDCT) accurately measures myocardial blood flow (MBF) using upslope and deconvolution methods. These d-MDCT MBF measurements show strong correlation with gold-standard microsphere techniques.

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Area of Science:

Cardiovascular imaging
Radiology
Medical physics

Background:

Assessing myocardial blood flow (MBF) is crucial for diagnosing and managing coronary artery disease.
Traditional methods for MBF assessment can be invasive or lack the spatial and temporal resolution needed for accurate quantification.

Purpose of the Study:

To evaluate the accuracy of dynamic 64-slice multidetector computed tomography (d-MDCT) in measuring myocardial blood flow (MBF).
To compare semiquantitative and quantitative analysis methods of first-pass d-MDCT with established microsphere techniques for MBF assessment.

Main Methods:

Adenosine stress d-MDCT imaging was performed on six dogs with induced left-anterior descending artery stenosis.
Time-attenuation curves were generated from regions of interest in the LAD and remote territories.
Myocardial perfusion was analyzed using model-based deconvolution and two upslope methods, then compared to microsphere MBF measurements.

Main Results:

Upslope-to-LV-upslope and upslope-to-LV-max ratios strongly correlated with MBF (R2 = 0.92 and R2 = 0.87, respectively).
Model-based deconvolution analysis modestly overestimated MBF compared to microspheres (3.0 ± 2.5 vs. 2.6 ± 2.7 mL/g/min).
Overall, MDCT-derived MBF showed strong correlation with microspheres (R = 0.91, P < 0.0001).

Conclusions:

d-MDCT MBF measurements using upslope and model-based deconvolution methods demonstrate good correlation with microsphere MBF.
These d-MDCT techniques show potential for clinical application, especially with advancements in MDCT scanner technology.
Integration with coronary angiography and next-generation MDCT scanners could enhance clinical utility.