Related Experiment Video
Updated: Jul 10, 2026

Preparation of 6-aminocyclohepta-2,4-dien-1-one Derivatives via Tricarbonyl(tropone)iron
Published on: August 12, 2019
Functionalization of 6-nitrobenzo[1,3]dioxole with carbonyl compounds via TDAE methodology
Ouassila Amiri-Attou1, Thierry Terme, Patrice Vanelle
1Laboratoire de Chimie Organique Pharmaceutique, CNRS-UMR 6517, Faculté de Pharmacie, 27 Bd Jean Moulin, 13385 Marseille Cx 5, France.
Abstract:
We report herein the synthesis of substituted 2-(6-nitrobenzo[1,3]dioxol-5-yl)-1- aryl ethanols and 2-(6-nitrobenzo[1,3]dioxol-5-yl)-propionic acid ethyl esters from the reaction of 5-chloromethyl-6-nitrobenzo[1,3]dioxole with various aromatic carbonyl and alpha- carbonyl ester derivatives using the tetrakis(dimethylamino)ethylene (TDAE) methodology.
Related Concept Videos
Nitrosation of Enols
Aldol Condensation with β-Diesters: Knoevenagel Condensation
Oxidation of Alkenes: Syn Dihydroxylation with Osmium Tetraoxide
Oxidation of Alkenes: Anti Dihydroxylation with Peroxy Acids
Keto–Enol Tautomerism: Mechanism
Reactions of Aldehydes and Ketones: Baeyer–Villiger Oxidation
The carbonyl center is activated by...

