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Updated: Jul 10, 2026

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
Published on: June 23, 2019
A novel synthesis of arylpyrrolo[1,2-a]pyrazinone derivatives
Fei Wang1, Jiawei Wang, Shoufang Zhang
1School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, 110016, PR China. wfei77502@sina.com
Abstract:
Some aryl-2-methyl-1-pyrrolo[1,2-a]pyrazinones were designed and prepared to study the Structure-Activity Relationships (SAR) of pyrrolo[1,2-a]pyrazinone derivatives. With methyl pyrrole-2-carboxylate as the starting material, the title compounds were prepared through N-alkylation and two novel cyclizations. Eleven aryl-2-methyl-1- pyrrolo[1,2-a]pyrazinone derivatives not previously reported in the literature are presented in this paper. Some of them show potent anti-inflammatory and analgesic activities.
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