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Updated: Jul 10, 2026

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
Published on: July 24, 2020
High-resolution optical coherence tomography over a large depth range with an axicon lens
Abstract:
In optical coherence tomography, axial and lateral resolutions are determined by the source coherence length and the numerical aperture of the sampling lens, respectively. Whereas axial resolution can be improved by use of a broadband light source, there is a trade-off between lateral resolution and focusing depth when conventional optical elements are used. We report on the incorporation of an axicon lens into the sample arm of an interferometer to overcome this limitation. Using an axicon lens with a top angle of 160 degrees , we maintained 10-microm or better lateral resolution over a focusing depth of at least 6 mm. In addition to having high lateral resolution, the focusing spot has an intensity that is approximately constant over a greater depth range than when a conventional lens is used.
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