[The role of thrombocytes in blood coagulation disorders in infectious pathology]

Platelets play the leading role in circulatory disorders seen in patients with infectious diseases. Endotoxinemia leads to platelet activation which shows up by the transformation of platelet forms from disk-shaped to spheroidal and by changes in aggregation and secretion. The degree of those changes correlates with the disease gravity. Experimental endotoxinemia (in vivo and in vitro experiments) demonstrated the same changes in the morphofunctional properties of platelets together with a possibility of correcting circulatory disorders by blockers of prostaglandin biosynthesis, such as indomethacin++, trental and emoxipine.