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Possible mechanisms underlying the special vulnerability of dopaminergic neurons
1Department of Pharmacology, University of Göteborg, Sweden.
Acta Neurologica Scandinavica. Supplementum
|January 1, 1991
Abstract:
Endogenous or exogenous agents may account for the special vulnerability of dopaminergic neutrons. The present paper deals primarily with the possible role of toxic quinoid metabolites of catechols formed by autoxidation. The study of 5-S-cysteinyl adducts of these metabolites may provide clues to underlying mechanisms. In addition these adducts may serve as markers of Parkinson's disease.