Related Experiment Video
Updated: Jul 10, 2026

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
Published on: April 17, 2013
[Pathology of benign thyroid tumor]
Kaori Kameyama1, Koichi Ito, Hiroshi Takami
1Division of Diagnostic Pathology, Keio University School of Medicine.
Abstract:
True benign neoplasm of the thyroid gland is only follicular adenoma, which is a tumor derived from follicular cells. Follicular adenoma is well-circumscribed, with no evidence of capsular or vascular invasion. The architectural pattern of follicular adenoma varies from trabecular to macrofollicular, and in most instances more than one architectural pattern is observed in one tumor. Adenomatous goiter, a hyperplastic lesion of follicles, is the most common tumorous lesion of thyroid gland. The gland is distorted with a nodular surface. The hyperplasia is followed by involution of the follicles leading to large follicles of varying size. Mature or immature teratoma is also observed in the thyroid gland. Mechanical implantation and parasitic nodule should not be misdiagnosed as lymph nodes harboring metastatic carcinoma.
Related Concept Videos
Hyperthyroidism II: Pathophysiology
Graves Disease II: Pathophysiology
Hypothyroidism II: Pathophysiology
The Thyroid Gland
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
Goiter
Hyperthyroidism I: Introduction
