Related Experiment Video
Updated: Jul 10, 2026

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo
Published on: May 16, 2020
[Takotsubo cardiomyopathy]
1Division of Cardiology, Saitama Medical University International Medical Center, Hidaka, Japan.
Insights
Takotsubo cardiomyopathy (TC), a condition mimicking heart attacks, involves temporary heart muscle weakening. Stress and elevated catecholamines, particularly during surgery, are linked to its development.
Area of Science:
- Cardiology
- Cardiovascular Physiology
Context:
- Takotsubo cardiomyopathy (TC) presents with symptoms similar to acute myocardial infarction.
- The condition is characterized by unique left ventricular ballooning and wall motion abnormalities.
- While the exact cause is unknown, stress is a common trigger.
Purpose:
- To review and comment on takotsubo cardiomyopathy in the perioperative period.
- To highlight the potential role of perioperative stress and catecholamine release in TC.
- To inform surgeons about TC in surgical patients.
Summary:
- Takotsubo cardiomyopathy (TC) is a transient left ventricular dysfunction mimicking myocardial infarction.
- Elevated plasma catecholamines suggest a significant role for sympathetic stimulation.
- Perioperative TC cases are increasingly reported, likely due to stress and catecholamine release during surgery.
Impact:
- Provides insights into the pathogenesis of TC, particularly stress-related mechanisms.
- Raises awareness among surgeons regarding TC in the perioperative setting.
- Contributes to understanding TC triggers and potential management strategies in surgical patients.
Abstract:
Transient left ventricular dysfunction with chest symptoms and electrocardiographic changes mimicing those of acute myocardial infarction is known as takotsubo cardiomyopathy (TC). Because early left ventriculography reveals peculiar wall motion abnormalities and a balloon-shaped left ventricle, this was named takotsubo. Although the pathogenesis of TC remains unclear, physical or emotional stress is common in the majority of reported cases. The central role of sympathetic stimulation in TC is suggested by elevations in plasma catecholamine. Recently, TC cases occurring in perioperative period have been reported. Excessive perioperative catecholamine release, following deep anxiety or physical stress including pain, is likely to cause TC. We provide a brief review of, and comments on TC in perioerative period for surgeons.
Related Concept Videos
Cardiomyopathy I: Introduction and Classification
Cardiomyopathy II: Dilated Cardiomyopathy
Cardiomyopathy III: Hypertrophic Cardiomyopathy
Cardiomyopathy IV: Restrictive Cardiomyopathy
Cardiomyopathy V: Interprofessional Care
Cardiomyopathy VI: Nursing Management

