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Related Concept Videos

Synthesis and Functions of Calcitonin00:51

Synthesis and Functions of Calcitonin

Calcitonin, a vital polypeptide hormone, regulates calcium levels within body fluids. It is released by the parafollicular cells, also known as C cells, situated in the follicular epithelium of the thyroid gland. Calcitonin responds to fluctuations in blood calcium levels and the influence of gastrointestinal hormones like gastrin and cholecystokinin.
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Sensitivity, Specificity, and Predicted Value01:13

Sensitivity, Specificity, and Predicted Value

In healthcare diagnostics, laboratory tests play a crucial role in identifying and diagnosing a wide range of medical conditions. However, interpreting test results is not always straightforward. An abnormal test result does not always confirm the presence of a disease, just as a normal result does not guarantee its absence. To assess the reliability of these diagnostic tools, healthcare practitioners rely on two key statistical indicators: sensitivity and specificity.
Sensitivity is the...

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Related Experiment Video

Updated: Jul 10, 2026

Detection and Quantification of Calcitonin Gene-Related Peptide (CGRP) in Human Plasma Using a Modified Enzyme-Linked Immunosorbent Assay
07:14

Detection and Quantification of Calcitonin Gene-Related Peptide (CGRP) in Human Plasma Using a Modified Enzyme-Linked Immunosorbent Assay

Published on: June 16, 2023

[Proper usage of procalcitonin].

Y Green1, P-A Petignat, A Perrier

  • 1Service de Médecine Interne Générale, Département de Médecine Interne, HUG, Genève.

Revue Medicale Suisse
|November 21, 2007
PubMed
Summary

Procalcitonin measurements aid in diagnosing infections, particularly septic shock in intensive care. While promising for other settings, its use in all febrile patients needs more evidence.

Area of Science:

  • Clinical diagnostics
  • Infectious disease management
  • Biomarker research

Background:

  • Procalcitonin (PCT) has been studied for 15 years as a diagnostic marker for infection.
  • Its use is widespread in febrile patients, but evidence for this broad application is limited.
  • PCT is established in intensive care for diagnosing septic shock, prognosis, and guiding antibiotic therapy duration.

Purpose of the Study:

  • To evaluate the role of procalcitonin as a diagnostic aid for suspected infections.
  • To assess the efficacy of procalcitonin in non-intensive care settings, specifically emergency departments.
  • To determine appropriate clinical scenarios for procalcitonin measurement.

Main Methods:

  • Review of studies evaluating procalcitonin measurement for suspected infections.

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Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
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Detection and Quantification of Calcitonin Gene-Related Peptide (CGRP) in Human Plasma Using a Modified Enzyme-Linked Immunosorbent Assay
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  • Analysis of procalcitonin's effectiveness in intensive care versus non-intensive care settings.
  • Assessment of procalcitonin's utility in emergency department patients with lower respiratory tract infections and acute febrile illness.

    • Main Results:

    • Procalcitonin is effective in intensive care for diagnosing septic shock, prognosis, and tailoring antibiotic treatment.
    • Studies in non-intensive care settings, like the emergency department, show encouraging but preliminary results.
    • Evidence for widespread use in all febrile patients is lacking.

    Conclusions:

    • Procalcitonin is a valuable tool in intensive care for managing severe infections.
    • Further research is needed to support the use of procalcitonin in broader, non-intensive care settings.
    • Current recommendations suggest restricting procalcitonin measurement to patients with severe infection criteria.