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Phase II study of ACNU as first-line treatment in advanced colorectal cancer
A Planting1, A Hoff, M van der Burg
1Department of Medical Oncology, Rotterdam Cancer Center/Dr. Daniel den Hoed Kliniek, The Netherlands.
Abstract:
Thirty-two patients with metastatic colorectal cancer were entered in a phase II study of ACNU as first-line treatment. ACNU was given at a dose of 100 mg/m2 i.v. every six weeks. In 30 evaluable patients we observed partial responses lasting 5 and 8 months in 2 patients with liver metastases, and stable disease in 4 patients. The toxicity mainly consisted of leuco- and trombocytopenia. We conclude that in this dose and schedule ACNU has only very limited activity in metastatic colorectal cancer.
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