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Effects of recombinant IL-4delta2 on human peripheral blood mononuclears
A N Silkov1, V A Gavrilenko, V V Denisova
1Institute of Clinical Immunology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk.
Abstract:
In human cells, expression of IL-4 gene involves alternative mRNA splicing. IL-4delta2 splice variant is an antagonist of full-length IL-4 protein and blocks its effect on the functional activity of immunocompetent cells. The effect of recombinant IL-4delta2 on cytokine-producing activity of human peripheral blood mononuclear cells is shown for the first time.
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