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A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation

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Published on: April 2, 2012

[Meningoradiculitis caused by herpes simplex virus type 2].

A E Bollen¹, A W Venema, K E Veldkamp

¹Wilhelmina Ziekenhuis Assen, Postbus 30.001, 9400 RA Assen. a.e.bollen@wza.nl

Nederlands Tijdschrift Voor Geneeskunde

|November 21, 2007

Summary

This summary is machine-generated.

Herpes simplex virus type 2 (HSV-2) can cause serious neurological conditions like meningoradiculitis and sacral polyradiculitis. Prompt diagnosis with PCR and treatment with acyclovir are crucial for recovery.

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Area of Science:

Neurology
Infectious Diseases
Virology

Background:

Herpes simplex virus type 2 (HSV-2) is a common cause of genital herpes.
Neurological complications of HSV-2 are less common but can be severe.

Observation:

A 24-year-old woman presented with fever, headache, facial palsy, and sacral nerve dysfunction.
Perianal lesions were observed, and cerebrospinal fluid analysis revealed lymphocytic pleocytosis.
Polymerase chain reaction (PCR) confirmed HSV-2 in cerebrospinal fluid and perianal lesions.

Findings:

The patient exhibited symptoms consistent with meningoradiculitis and sacral polyradiculitis.
MRI revealed abnormalities in the cauda equina.
Intravenous acyclovir treatment led to complete recovery.

Implications:

HSV-2 can manifest as neurological syndromes, including meningitis and polyradiculitis, even without overt genital symptoms.
Early diagnosis via PCR of cerebrospinal fluid is vital.
Timely initiation of acyclovir therapy is essential for favorable outcomes in HSV-2 neurological infections.