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Updated: Jul 10, 2026

Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds
08:54

Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds

Published on: February 14, 2018

Update on new antifungal therapy

Paul Juang1

  • 1Department of Pharmacy Practice, St Louis College of Pharmacy, 4588 Parkview Place, St Louis, MO 63110, USA. pjuang@stlcop.edu

AACN Advanced Critical Care
|November 21, 2007
PubMed

Insights

New antifungal agents, micafungin, anidulafungin, and posaconazole, offer improved treatment options for invasive fungal infections. This review details their efficacy, usage, and safety profiles for clinicians.

Area of Science:

  • Infectious Diseases
  • Pharmacology
  • Mycology

Background:

  • Rising rates of fungal infections, morbidity, and mortality necessitate novel antifungal therapies.
  • Echinocandins and triazoles represent key classes of antifungal medications.

Purpose of the Study:

  • To review the clinical efficacy of three new antifungal agents: micafungin, anidulafungin, and posaconazole.
  • To outline approved uses, dosages, and administration guidelines for these agents.

Main Methods:

  • Review of clinical efficacy data for micafungin, anidulafungin, and posaconazole.
  • Analysis of approved indications, dosing regimens, and administration techniques.
  • Evaluation of drug interactions, precautions, and adverse effects.

Main Results:

  • Micafungin and anidulafungin are echinocandins inhibiting 1,3-beta-D-glucan synthase.
  • Posaconazole is a triazole inhibiting ergosterol synthesis, effective against Candida and molds.
  • These agents demonstrate promising efficacy in treating and preventing invasive fungal infections.

Conclusions:

  • Micafungin, anidulafungin, and posaconazole represent significant advancements in antifungal treatment.
  • Understanding their specific mechanisms, efficacy, and safety is crucial for optimal patient care.

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