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Published on: April 28, 2023
Serum selenium concentration in patients with Wilson's disease
Renata Swiatkowska-Stodulska1, Wojciech Dejneka, Irena Jabłońska-Kaszewska
1Department of Internal Medicine, Endocrinology and Hemostatic Disorders, Medical University of Gdańsk, Poland. domixto@poczta.onet.pl
Serum selenium levels in Wilson's disease patients are comparable to healthy individuals, suggesting a balanced antioxidant status in treated patients. Selenium levels did not differ significantly between patient and control groups.
Area of Science:
- Biochemistry
- Genetics
- Toxicology
Background:
- Wilson's disease is a genetic disorder of copper metabolism leading to toxic accumulation.
- Copper overload damages organs via free radicals and lipid peroxidation.
- Antioxidant factor behavior in Wilson's disease requires further evaluation.
Purpose of the Study:
- To assess blood serum selenium concentrations in Wilson's disease patients.
- To evaluate the antioxidant status in Wilson's disease.
Main Methods:
- Atomic absorption spectroscopy with hydride generation was used.
- Blood serum selenium levels were measured in 25 Wilson's disease patients and 30 healthy controls.
- Correlations between selenium and various biochemical markers were analyzed.
Main Results:
- No statistically significant difference in serum selenium was found between Wilson's disease patients and healthy controls.
- A significant correlation was observed between selenium concentration and aspartate aminotransferase activity.
- No significant differences in selenium levels were noted among different forms of Wilson's disease.
Conclusions:
- Treated Wilson's disease patients exhibit a serum selenium concentration comparable to healthy controls.
- Serum selenium may serve as an indicator of antioxidant status in Wilson's disease.
- The study suggests that antioxidant status, as measured by serum selenium, is maintained in treated Wilson's disease.
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