Recent randomized controlled trials in hepatectomy.

Area of Science:

• Hepatobiliary Surgery
• Surgical Research
• Evidence-Based Medicine

Background:

• Randomized controlled trials (RCTs) are increasingly prevalent in liver surgery.
• A significant portion of these RCTs originate from Asia, particularly Japan and China.
• Hepatic surgery research has expanded over the last decade.

Purpose of the Study:

• To review recent randomized controlled trials (RCTs) in hepatectomy over the past decade.
• To provide the most current evidence on perioperative procedures in liver surgery.
• To synthesize findings from larger RCTs (sample size ≥50).

Main Methods:

• Systematic review of RCTs investigating hepatectomy.
• Focus on trials published within the last ten years.
• Exclusion of small-scale trials with fewer than 50 participants.

Main Results:

• RCTs on liver ischemia, including vascular occlusion and ischemia/reperfusion injury management, are most common.
• Other frequent RCT topics include liver parenchyma transection devices, hilar approach techniques, and postoperative chemotherapy/complications.
• The majority of reviewed RCTs were conducted in Asian countries.

Conclusions:

• Recent RCTs provide substantial evidence for perioperative management in hepatectomy.
• Key research areas include liver ischemia control and advanced surgical techniques.
• The findings reflect a growing body of high-quality evidence in liver surgery, particularly from Asian research centers.