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Deep Dermal Injection As a Model of Candida albicans Skin Infection for Histological Analyses
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Published on: June 13, 2018

Superficial oral fungal infections

L P Samaranayake1

  • 1University of Hong Kong.

Current Opinion in Dentistry
|August 1, 1991
PubMed

Insights

Cellular immune defects can worsen fungal infections, leading to new oral candidiasis forms, especially with human immunodeficiency virus. Host blood group secretor status may influence oral candidiasis development.

Area of Science:

  • Immunology
  • Mycology
  • Infectious Diseases

Background:

  • Fungal infections, particularly oral candidiasis, are significantly influenced by cellular immune system status.
  • The human immunodeficiency virus (HIV) pandemic has led to the emergence of novel clinical variants of oral candidoses and rare mycoses.
  • Classification of oral candidoses is evolving due to new clinical entities.

Purpose of the Study:

  • To review the classification of oral candidoses.
  • To discuss the role of host factors, such as blood group secretor status, in oral candidiasis pathogenesis.
  • To evaluate a new mouse model for studying host-parasite interactions in oral candidiasis.

Main Methods:

  • Review of existing literature on oral candidiasis classification and pathogenesis.
  • Analysis of data implicating host blood group secretor status in infectious states.
  • Evaluation of a newly developed mouse model for oral candidiasis research.

Main Results:

  • Angular cheilitis, a common Candida infection, shows varied prevalence in the elderly (West) versus young (Asia), potentially linked to factors like anemia.
  • Host blood group secretor status is identified as a novel cofactor potentially playing a role in the pathogenesis of oral candidiasis.
  • A new mouse model is presented as an alternative to the rat model for investigating host-parasite interactions in oral candidiasis.

Conclusions:

  • Defects in cellular immunity are critical in fungal infections, influencing oral candidiasis presentation.
  • Host-specific factors, including blood group secretor status, warrant further investigation in oral candidiasis pathogenesis.
  • The new mouse model offers a valuable tool for future research into oral candidiasis and host-parasite dynamics.

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