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Related Concept Videos

Adrenal Gland Disorders01:27

Adrenal Gland Disorders

Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Cushing Syndrome II: Pathophysiology01:19

Cushing Syndrome II: Pathophysiology

Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features of the...
Cushing Syndrome I: Introduction01:26

Cushing Syndrome I: Introduction

Cushing syndrome refers to the collection of clinical manifestations that arise when tissues are exposed to excessive amounts of cortisol or cortisol-like medications over an extended period. Cortisol, a glucocorticoid produced by the adrenal cortex, regulates metabolism, immune responses, and the body’s adaptation to stress. When its concentration remains chronically elevated, these physiological pathways become dysregulated, resulting in the characteristic features of the syndrome.Exogenous...
Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
Hormones of the Adrenal Glands01:31

Hormones of the Adrenal Glands

Adrenal hormones play a pivotal role in maintaining the body's electrolyte balance and orchestrating responses to stress, showcasing the intricate functions of the adrenal cortex and medulla.
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and corticosterone...
Anatomy of the Adrenal Glands01:17

Anatomy of the Adrenal Glands

The adrenal or supra-renal glands, situated above the kidneys and aligned with the twelfth rib, are paired pyramid-shaped structures crucial for the body's stress response. During stress, these glands secrete hormones vital for adaptive physiological reactions.
These glands possess a distinctive yellow tinge due to the stored cholesterol and fatty acids required for hormone synthesis. They are encased in a fibrous capsule and cushioned by fat.
The adrenal gland comprises two distinct regions...

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Related Experiment Video

Updated: Jul 10, 2026

A Novel Method: Super-selective Adrenal Venous Sampling
06:08

A Novel Method: Super-selective Adrenal Venous Sampling

Published on: September 15, 2017

Adrenal hypersecretion.

Bandula Wijesiriwardene1, Deepthi C De Silva

  • 1Colombo South Teaching Hospital, Kalubowila, Sri Lanka. bandulawije@lycos.com

The Ceylon Medical Journal
|November 21, 2007
PubMed
Summary

Adrenal gland hypersecretion causes hypertension. This article covers Conn syndrome, Cushing syndrome, and pheochromocytoma, detailing their clinical features, diagnosis, treatment, and incidental adrenal tumor management.

Area of Science:

  • Endocrinology
  • Oncology

Background:

  • Adrenal gland hypersecretion is a significant factor in hypertension.
  • Common causes include Conn syndrome, Cushing syndrome, and pheochromocytoma.

Purpose of the Study:

  • To review the clinical features, diagnostic approaches, and treatment strategies for adrenal hypersecretion syndromes.
  • To outline the management of incidentally discovered adrenal tumors (incidentalomas).

Main Methods:

  • Literature review of endocrine and oncological studies.
  • Synthesis of clinical guidelines and case reports.

Main Results:

  • Detailed descriptions of the distinct clinical presentations of Conn syndrome, Cushing syndrome, and pheochromocytoma.
  • Established diagnostic criteria and current therapeutic options for each condition.

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Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions

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Isolation, Fixation, and Immunofluorescence Imaging of Mouse Adrenal Glands

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Last Updated: Jul 10, 2026

A Novel Method: Super-selective Adrenal Venous Sampling
06:08

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Published on: September 15, 2017

Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions
04:33

Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions

Published on: March 12, 2019

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08:37

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Published on: October 2, 2018

  • Guidelines for the evaluation and management of adrenal incidentalomas based on tumor characteristics and patient factors.

    • Conclusions:

    • Accurate diagnosis and timely treatment of adrenal hypersecretion are crucial for managing hypertension and associated comorbidities.
    • A systematic approach is necessary for the effective management of adrenal incidentalomas to rule out malignancy and hormonal activity.