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A novel in vitro chemosensitivity test using materials collected by endoscopic biopsy
T Hirai1, K Kawano, N Hirabayashi
1Department of Surgery, Hiroshima University, Japan.
Anti-Cancer Drugs
|June 1, 1991
Summary
Chemosensitivity testing using the adenosine triphosphate (ATP) assay on esophageal tumor biopsies shows high correlation with other tests. This method accurately predicts clinical sensitivity and resistance, aiding treatment decisions.
Area of Science:
- Oncology
- Biomedical Engineering
- Clinical Diagnostics
Background:
- Esophageal tumors present treatment challenges.
- Accurate chemosensitivity testing is crucial for personalized medicine.
- Current methods may have limitations in accessibility or application.
Purpose of the Study:
- To evaluate the utility of the adenosine triphosphate (ATP) assay for chemosensitivity testing in esophageal tumors.
- To assess the correlation of ATP assay results with other established chemosensitivity tests.
- To determine the predictive accuracy of the ATP assay for clinical sensitivity and resistance.
Main Methods:
- Cells were collected from esophageal tumors via endoscopic biopsy.
- Chemosensitivity was assessed using the adenosine triphosphate (ATP) assay.
- ATP assay results were correlated with other chemosensitivity testing methods.
Main Results:
- The ATP assay demonstrated a correlation exceeding 80% with most other chemosensitivity tests.
- The predictive rate for clinical sensitivity was 77.8%.
- The predictive rate for clinical resistance was 68.8%, with an overall predictive accuracy of 72.0%.
Conclusions:
- The adenosine triphosphate (ATP) assay is a useful method for chemosensitivity testing in esophageal cancer.
- This assay shows strong correlation and predictive value, supporting its clinical application.
- Results suggest expanding the use of chemosensitivity testing for inoperable and preoperable esophageal tumors.