Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Glucose Absorption Into the Small Intestine01:26

Glucose Absorption Into the Small Intestine

Complex carbohydrates consumed cannot be absorbed into the small intestine in their original form. First, they must be hydrolyzed to a monosaccharide form such as glucose or galactose. These monosaccharides are then transported across the intestinal membrane and into the blood via transcellular transport. The intestinal epithelial cells allow the movement of these monosaccharides with a defined 'entry' through membrane transporter proteins present on their apical membrane and 'exit' via the...
Transcellular Transport of Solutes01:23

Transcellular Transport of Solutes

Transcellular transport of solutes is the movement of substances like monosaccharides and amino acids through polarized cells. This transport mechanism is primarily seen in epithelial and endothelial cells aided by membrane transport proteins such as channels and transporters. The tight junctions between these cells confine the membrane proteins to the two sides of the cell. The epithelial cells have distinct apical and basolateral domains. In contrast, the endothelial cells show the luminal...
Membrane Proteins01:30

Membrane Proteins

Plasma membranes have integral transmembrane proteins involved in facilitated transport. These proteins are collectively referred to as transport proteins, and they function as either channels for the material or as carriers themselves. Channel proteins have hydrophilic domains exposed to the intracellular and extracellular fluids and a hydrophilic channel through their core that provides a hydrated opening for solutes to pass through the membrane layers. Passage through the channel allows...
Glucose Transporters01:27

Glucose Transporters

Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
Secondary Active Transport01:32

Secondary Active Transport

One example of how cells use the energy contained in electrochemical gradients is demonstrated by glucose transport into cells. The ion vital to this process is sodium (Na+), which is typically present in higher concentrations extracellularly than in the cytosol. Such a concentration difference is due, in part, to the action of an enzyme "pump" embedded in the cellular membrane that actively expels Na+ from a cell. Importantly, as this pump contributes to the high concentration of...
Secondary Active Transport01:55

Secondary Active Transport

One example of how cells use the energy contained in electrochemical gradients is demonstrated by glucose transport into cells. The ion vital to this process is sodium (Na+), which is typically present in higher concentrations extracellularly than in the cytosol. Such a concentration difference is due, in part, to the action of an enzyme “pump” embedded in the cellular membrane that actively expels Na+ from a cell. Importantly, as this pump contributes to the high concentration of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Quantitative evaluation of China's smart aging healthcare policy under the background of silver economy development: based on PMC model.

Frontiers in public health·2026
Same author

Metabolome-driven rhizosphere microbiome assembly determining the health of medicinal herb (Angelica sinensis) against root rot.

Microbiome·2026
Same author

Linear RAG scanning mediates editing of Igκ variable region repertoires.

Nature·2026
Same author

Specific inhibition of NLRP3 inflammasome by a Smurf1 inhibitor <i>in vitro</i> and <i>in vivo</i>.

Open medicine (Warsaw, Poland)·2026
Same author

Aquaporin 4 knockdown alleviates traumatic brain edema and reduces neuronal axonal growth cone collapse via the RhoA/ROCK pathway.

Neurobiology of disease·2026
Same author

Enhancing hospital workforce planning, scheduling, and performance evaluation through an AI-driven human resource management system.

Scientific reports·2026

Related Experiment Video

Updated: Jul 10, 2026

Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution
11:55

Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution

Published on: August 16, 2016

Permeability control of glucose-sensitive nanoshells.

Yongjun Zhang1, Ying Guan, Shuiqin Zhou

  • 1Department of Chemistry of College of Staten Island, and The Graduate Center, The City University of New York, 2800 Victory Boulevard, Staten Island, New York 10314, USA.

Biomacromolecules
|November 21, 2007
PubMed
Summary

Researchers developed core-shell microgels with tunable permeability. The phenylboronic acid-conjugated shell effectively retains degraded core polymers, enabling controlled release for potential insulin delivery systems.

More Related Videos

NiO Nanoflowers for Non-Enzymatic Amperometric Detection of Glucose
11:04

NiO Nanoflowers for Non-Enzymatic Amperometric Detection of Glucose

Published on: December 30, 2025

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
18:57

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers

Published on: October 17, 2013

Related Experiment Videos

Last Updated: Jul 10, 2026

Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution
11:55

Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution

Published on: August 16, 2016

NiO Nanoflowers for Non-Enzymatic Amperometric Detection of Glucose
11:04

NiO Nanoflowers for Non-Enzymatic Amperometric Detection of Glucose

Published on: December 30, 2025

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
18:57

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers

Published on: October 17, 2013

Area of Science:

  • Polymer Science
  • Materials Science
  • Biomedical Engineering

Background:

  • Hydrogels are crucial for drug delivery, but controlling their nanoscale permeability is challenging.
  • Core-shell microgel structures offer potential for advanced drug release applications.

Purpose of the Study:

  • To design and synthesize core-shell microgels with tunable permeability for controlled release.
  • To investigate the role of phenylboronic acid (PBA) conjugation in shell permeability and polymer retention.
  • To explore the potential of these microgels in self-regulated insulin delivery systems.

Main Methods:

  • Synthesis of core-shell microgels with degradable PNIPAM core and PBA-conjugated P(NIPAM-PBA) shell.
  • Laser light scattering to analyze volume phase transitions and core degradation.
  • Turbidity measurements to monitor the release of degraded core polymer chains.

Main Results:

  • The PBA-modified P(NIPAM-PBA) nanoshell effectively retained degraded core polymers due to its condensed structure.
  • Shell permeability was controllable via temperature and pH adjustments.
  • Glucose complexation with PBA groups enhanced shell swelling and permeability.

Conclusions:

  • Core-shell microgels with PBA-conjugated shells demonstrate controllable permeability.
  • These findings are significant for developing glucose-sensitive hydrogels for self-regulated insulin delivery.
  • The study provides a foundation for designing advanced responsive drug delivery systems.