The CpG motif: implications for clinical immunology
1Veterans Affairs Medical Center, Iowa City, Iowa, USA. arthur-krieg@uiowa.edu
Abstract:
The immune system appears to have evolved a mechanism to detect prokaryotic nucleic acids based on their content of unmethylated CpG dinucleotides in particular base contexts. This response promotes the activation of antigen-specific B cells and the secretion of T helper-1-like cytokines. Preliminary animal studies indicate the potential therapeutic utility of CpG DNA as a vaccine adjuvant, and for the immunotherapy of cancer and allergic diseases. On the other hand, CpG DNA can also serve as a trigger for the sepsis syndrome and may have a pathogenic role in certain inflammatory immune-mediated diseases.
More Related Videos
Related Concept Videos
Immunoglobulin-like Cell Adhesion Molecules
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
cAMP-dependent Protein Kinase Pathways
G Protein-coupled Receptors
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
GPCRs Regulate Adenylyl Cylase Activity
Two...
Pharmacogenomics: Identification of New Drug Targets
Transducer Mechanism: G Protein–Coupled Receptors
GPCRs are also called heptahelical, 7TM, or...


