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Updated: Jul 10, 2026
Preparation Of Neovascular Tissues from Human Glioma Tissues for Quantitative Proteomics Analysis of Tumor Angiogenesis
Published on: March 20, 2026
Inhibition of angiogenesis and invasion in malignant gliomas
Andrew Chi1, Andrew D Norden, Patrick Y Wen
1Center for Neuro-Oncology, Dana-Farber/Brigham & Women's Cancer Center, Division of Neuro-Oncology, Department of Neurology, Brigham & Women's Hospital, SW430D, 44 Binney Street, Boston, MA 02115, USA. achi@partners.org
Abstract:
Malignant gliomas confer a dismal prognosis. As the molecular events that underlie tumor angiogenesis are elucidated, angiogenesis inhibition is emerging as a promising therapy for recurrent and newly diagnosed tumors. Data from animal studies suggest that angiogenesis inhibition may promote an invasive phenotype in tumor cells. This may represent an important mechanism of resistance to antiangiogenic therapies. Recent studies have begun to clarify the mechanisms by which glioma cells detach from the tumor mass, remodel the extracellular matrix and infiltrate normal brain. An array of potential therapeutic targets exists. Combination therapy with antiangiogenic and novel anti-invasion agents is a promising approach that may produce a synergistic antitumor effect and a survival benefit for patients with these devastating tumors.
Insights
Angiogenesis inhibition shows promise for malignant gliomas but may enhance invasion. Combining antiangiogenic and anti-invasion therapies could improve outcomes for patients with these aggressive brain tumors.
Area of Science:
- Neuro-oncology
- Cancer Biology
- Molecular Medicine
Background:
- Malignant gliomas have a poor prognosis, necessitating novel therapeutic strategies.
- Tumor angiogenesis is a key process in glioma progression and a target for therapy.
- Emerging evidence suggests antiangiogenic therapies may paradoxically promote glioma cell invasion.
Purpose of the Study:
- To review the role of angiogenesis in malignant gliomas.
- To explore the potential for antiangiogenic therapies in treating gliomas.
- To discuss the mechanisms of glioma cell invasion and potential therapeutic targets.
Main Methods:
- Literature review of preclinical and clinical studies on glioma angiogenesis and invasion.
- Analysis of molecular mechanisms underlying glioma cell detachment, matrix remodeling, and infiltration.
- Evaluation of therapeutic strategies targeting angiogenesis and invasion.
Main Results:
- Angiogenesis inhibition is a promising approach for malignant gliomas, particularly recurrent or newly diagnosed tumors.
- Animal studies indicate that blocking angiogenesis may increase glioma cell invasiveness, potentially leading to therapeutic resistance.
- Mechanisms of glioma cell invasion, including detachment and extracellular matrix remodeling, are being elucidated, revealing therapeutic targets.
Conclusions:
- Combination therapy targeting both angiogenesis and invasion presents a promising strategy for malignant gliomas.
- Synergistic effects between antiangiogenic and anti-invasion agents may offer improved antitumor activity.
- This combined approach holds potential for a survival benefit in patients with malignant gliomas.
