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Updated: Jul 10, 2026

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells
Published on: February 21, 2014
The role of estrogen receptor in melanoma
Atsushi Tanemura1, Anneke Q van Hoesel, Takuji Mori
1John Wayne Cancer Institute, Department of Molecular Oncology, 2200 Santa Monica Blvd., Santa Monica, CA 90404, USA.
Abstract:
The estrogen receptor (ER) belongs to the group of sex hormone receptors and binds the biologically active form of estrogen, 17beta-estradiol. Expression of ER in tumor tissue is a well-established prognostic marker in breast cancer. The role of ER has been extensively studied in several other types of human cancers. This report investigates the potential role of ER as a surrogate marker for predicting melanoma progression, response to therapy, and patient survival. In addition, the authors review what is known, so far, about ER signaling pathways and their potential role in carcinogenesis and progression of cutaneous melanoma. Possibilities and limitations of using ER as a therapeutic target in the treatment of melanoma is also discussed.
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