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Updated: Jul 10, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
Multiple myeloma, chronic lymphocytic leukaemia and associated precursor diseases
1National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. landgreo@mail.nih.gov
Abstract:
Multiple myeloma and chronic lymphocytic leukaemia share common biological and clinical features including the presence of defined precursor conditions (monoclonal gammopathy of undetermined significance and monoclonal B-cell lymphocytosis respectively). Here, we discuss evidence from the literature on the potential aetiological roles for genetic and chronic immune stimulatory factors on the pathway from precursor to malignancy. Also, we speculate on the relationship between precursor and malignancy and talk about future directions and gaps in the literature.
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