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Related Experiment Videos

Cell cycle-regulated and proliferation stimulus-responsive genes.

R Hofbauer1, D T Denhardt

  • 1Institut für Molekularbiologie, Universität Wein, Vienna, Austria.

Critical Reviews in Eukaryotic Gene Expression
|January 1, 1991
PubMed
Summary
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Cell cycle gene expression is regulated at multiple levels, influenced by signals and cell type. Understanding these mechanisms is key to cell proliferation and organism development.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Genetics

Background:

  • Cell cycle progression involves intricate gene expression regulation.
  • The relationship between cell cycle and gene expression can be causal or correlative.
  • Regulatory mechanisms vary significantly across different cell types and organisms.

Purpose of the Study:

  • To review genes with cell cycle-dependent expression.
  • To discuss the regulatory mechanisms underlying cell cycle gene expression.
  • To explore the implications of cell cycle regulation in different cellular contexts.

Main Methods:

  • Literature review of cell cycle and gene expression studies.
  • Analysis of regulatory mechanisms at translational, post-translational, and transcriptional levels.

Related Experiment Videos

  • Comparison of cell cycle regulation in various eukaryotic cells, including transformed and untransformed cell lines.

    • Main Results:

    • Cell cycle regulation occurs at multiple levels: translational, post-translational, and transcriptional.
    • Early embryonic cell divisions rely heavily on post-translational modifications (e.g., p34cdc2, cyclins).
    • Quiescent cells exiting G0 require new gene transcription, while proliferating cells show more post-transcriptional/post-translational control.

    Conclusions:

    • Cell cycle control is context-dependent, varying with cell type and organism.
    • Growth factors and extracellular signals are crucial for normal cell cycle progression.
    • Aberrant regulation of key genes (e.g., p53, RB) is observed in transformed cells.
    • Higher eukaryotic cells have limited divisions (mortal), unlike immortalized cell lines or stem cells.