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Updated: Jul 10, 2026

Quantitative Measurement of γ-Secretase-mediated Amyloid Precursor Protein and Notch Cleavage in Cell-based Luciferase Reporter Assay Platforms
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Quantitative Measurement of γ-Secretase-mediated Amyloid Precursor Protein and Notch Cleavage in Cell-based Luciferase Reporter Assay Platforms

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Interleukin-1 beta up-regulates TACE to enhance alpha-cleavage of APP in neurons: resulting decrease in Abeta

Yuriko Tachida1, Kazuhiro Nakagawa, Takashi Saito

  • 1Glyco-chain Functions Laboratory, Supra-biomolecular System Group, Frontier Research System, The Institute of Physical and Chemical Research (RIKEN), Saitama, Japan.

Journal of Neurochemistry
|November 21, 2007
PubMed
Summary

Interleukin-1beta (IL-1beta) surprisingly reduces amyloid-beta production by promoting alpha-cleavage over beta-cleavage. This suggests IL-1beta signaling could be a therapeutic target for Alzheimer's disease.

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