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Related Concept Videos

Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
Standards of Care II01:19

Standards of Care II

Nurses bear specific legal responsibilities under several federal statutes, including:
Clinically Relevant Drug Product Specifications: Methods of Establishment01:29

Clinically Relevant Drug Product Specifications: Methods of Establishment

Product specifications define the acceptable quality of a pharmaceutical product by ensuring identity, purity, potency, and strength. These specifications serve as benchmarks during development, manufacturing, and post-approval quality control. Clinically relevant specifications are particularly important because they directly relate to a drug's safety and efficacy in clinical use.Dissolution studies are critical biopharmaceutic tools that link in vitro behavior to in vivo performance. They...
Standards of Care I01:22

Standards of Care I

Federal statutes profoundly impact nursing practice, providing critical guidelines to ensure patient care is equitable, accessible, and of the highest quality. The following laws address distinct aspects of healthcare provision and patient rights:

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Related Experiment Videos

Figures in clinical trial reports: current practice & scope for improvement.

Stuart J Pocock1, Thomas G Travison, Lisa M Wruck

  • 1London School of Hygiene and Tropical Medicine, London, UK. stuart.pocock@lshtm.ac.uk

Trials
|November 21, 2007
PubMed
Summary

Clinical trial reports often lack guidance on figure use. This study evaluates current practices and offers guidelines for improving the presentation of key figures like flow diagrams and Kaplan-Meier plots.

Related Experiment Videos

Area of Science:

  • Medical Research
  • Clinical Trials
  • Scientific Publishing

Background:

  • Figures are common in clinical trial publications, yet specific guidance on their optimal use is lacking.
  • The selection and presentation of results as figures require clearer standards.

Purpose of the Study:

  • To assess the current utilization of figures in clinical trial reports.
  • To provide evidence-based recommendations for enhancing figure presentation in future publications.

Main Methods:

  • A systematic survey of 77 randomized controlled trial reports from five general medical journals was conducted.
  • Figures were quantified by type and critically evaluated for style, content, clarity, and suitability.

Main Results:

  • Most reports included 1-3 figures, with flow diagrams, Kaplan-Meier plots, Forest plots, and repeated measures over time comprising 92% of all figures.
  • Significant variability in the style and content of these common figure types was observed, highlighting areas for improvement.

Conclusions:

  • Authors can significantly enhance their clinical trial reports by improving figure selection, presentation style, labeling, and content.
  • Specific attention is needed to standardize the four most prevalent figure types used in trial reporting.