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Related Concept Videos

Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not related to...

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Updated: Jul 10, 2026

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice
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Liver involvement in multiple myeloma.

Meghana S Bhandari1, Amitabha Mazumder, David H Vesole

  • 1St. Vincent's Comprehensive Cancer Center, New York, NY 10011, USA.

Clinical Lymphoma & Myeloma
|November 21, 2007
PubMed
Summary
This summary is machine-generated.

Multiple myeloma (MM) rarely causes acute liver disease. This case highlights MM presenting as cholestatic hepatitis due to plasma cell infiltration of the liver.

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Area of Science:

  • Hematology
  • Hepatology
  • Oncology

Background:

  • Multiple myeloma (MM) is a plasma cell malignancy primarily affecting the bone marrow.
  • Liver involvement in MM is rare, often presenting insidiously or mimicking other liver diseases.

Observation:

  • A 55-year-old woman with MM presented with painless jaundice and abnormal liver function tests.
  • Initial investigations revealed elevated liver enzymes and a high white blood cell count with circulating plasma cells.
  • Myeloma markers included IgG lambda monoclonal protein and Bence-Jones proteinuria.

Findings:

  • Liver biopsy confirmed diffuse portal and sinusoidal infiltration by plasma cells with lambda light-chain restriction.
  • The patient's presentation mimicked acute cholestatic hepatitis without signs of chronic liver disease.

Implications:

  • This case underscores the importance of considering MM in the differential diagnosis of unexplained acute liver disease, particularly cholestatic patterns.
  • Early recognition and diagnosis of hepatic MM are crucial for appropriate management and improved patient outcomes.
  • Further research into the mechanisms and clinical spectrum of liver involvement in MM is warranted.