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Related Experiment Video

Updated: Jun 29, 2026

Flow Cytometric Analysis of Particle-bound Bet v 1 Allergen in PM10
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Published on: November 19, 2016

Allergens retained in clothing.

Susan Nedorost1, Margaret Kessler, Thomas McCormick

  • 1University Hospitals of Cleveland, Cleveland, OH, USA.

Dermatitis : Contact, Atopic, Occupational, Drug
|November 21, 2007
PubMed
Summary
This summary is machine-generated.

Persistent dermatitis may occur when allergens, especially high-molecular-weight ones from ointments, remain in clothing after washing. This allergen retention can hinder healing even with allergen avoidance.

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Area of Science:

  • Dermatology
  • Allergology
  • Clinical Chemistry

Background:

  • Persistent dermatitis despite allergen avoidance suggests incomplete removal of causative agents.
  • Allergen retention in clothing is a potential cause of treatment failure in allergic contact dermatitis.

Observation:

  • Patients with persistent dermatitis often comply with allergen avoidance but show symptoms in areas covered by tight clothing.
  • Analysis of contact dermatitis cases revealed specific allergen characteristics linked to clothing retention.

Findings:

  • High-formula-weight allergens and those in ointments are poorly soluble in standard laundry detergents and water.
  • These recalcitrant allergens can persist in fabric fibers, leading to ongoing skin exposure.

Implications:

  • Dermatologists should consider allergen retention in clothing for patients with partial clearing of dermatitis after 1 month of avoidance.
  • Recommending new clothing may be necessary to resolve recalcitrant allergic contact dermatitis.
  • Understanding allergen solubility is key to managing persistent cases.