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Updated: Jul 10, 2026
11:30
A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
Published on: June 2, 2022
Intractable wounds caused by calcific uremic arteriolopathy treated with bisphosphonates
Takaaki Hanafusa1, Yuji Yamaguchi, Mamori Tani
1Department of Dermatology, Osaka University Graduate School of Medicine, Osaka, Japan.
Journal of the American Academy of Dermatology
|November 21, 2007
Summary
Bisphosphonates may effectively treat calcific uremic arteriolopathy (calciphylaxis) and associated ulcers. This case study suggests bisphosphonates, alongside sevelamer hydrochloride, can heal intractable ulcers by managing calcium-phosphorus levels.
Area of Science:
- Nephrology
- Dermatology
- Vascular Medicine
Background:
- Calcific uremic arteriolopathy (calciphylaxis) is a severe condition affecting small vessels, often seen in end-stage renal disease patients.
- It can lead to intractable skin necrosis and sepsis due to rapid progression.
- Current treatment options for calciphylaxis are limited.
Observation:
- A hemodialysis patient with chronic renal failure presented with bilateral leg ulcers due to calciphylaxis.
- Aggressive debridement initially worsened the skin condition, mimicking pyoderma gangrenosum.
Findings:
- Treatment with bisphosphonates (etidronate disodium) and sevelamer hydrochloride led to ulcer healing.
- This was achieved by effectively lowering calcium-phosphorus levels.
- Bisphosphonates may reduce ectopic calcification in blood vessels.
Implications:
- Bisphosphonates show potential as a therapeutic agent for calciphylaxis.
- This approach may also benefit patients with arteriosclerosis obliterans.
- Further research is needed to confirm efficacy in a larger patient cohort.
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