The histopathologic spectrum of psoriasis
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Updated: Jul 10, 2026

SCAnED - An Open-source Skin Segmentation Macro for Semi-automated Cell and Nuclei Detection in Epidermal and Dermal Skin Compartments
Published on: August 8, 2025
Michael Murphy1, Philip Kerr, Jane M Grant-Kels
1Division of Dermatopathology, Department of Dermatology, University of Connecticut Health Center, Farmington, CT 06030, USA.
Abstract:
Psoriasis is the prototype of a group of cutaneous disorders (psoriasiform dermatitides) that show psoriasiform epidermal hyperplasia, defined as regular elongation of the rete ridges with preservation of the rete ridge-dermal papillae pattern. Depending on whether the lesion is early or resolving, psoriasiform epidermal changes may be subtle or prominent. Other histologic clues to the diagnosis of psoriasis include more dilated and tortuous papillary blood vessels, neutrophils within the epidermis associated with spongiosis (spongiform pustules), neutrophils beneath the cornified layer (subcorneal pustules), neutrophils within the cornified and parakeratotic horn, hypogranulosis, and more keratinocytic mitotic figures above the basal cell layer.
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