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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.01:25

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Chronic Obstructive Pulmonary Disease IV: Clinical Manifestations01:19

Chronic Obstructive Pulmonary Disease IV: Clinical Manifestations

Chronic Obstructive Pulmonary Disease, or COPD, is a long-term condition marked by persistent and only partially reversible airflow limitation. It involves two overlapping conditions—chronic bronchitis and emphysema—which often co-appear but differ in dominant symptoms and underlying mechanisms.Chronic Bronchitis FeaturesChronic bronchitis presents with a persistent productive cough and thick, sometimes purulent mucus due to airway inflammation, enlarged mucus glands, and goblet cell...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...

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Related Experiment Video

Updated: Jul 10, 2026

Measuring Psoriasis Severity at Home
02:28

Measuring Psoriasis Severity at Home

Published on: March 1, 2024

Comorbidities in psoriasis.

Enno Christophers1

  • 1Department of Dermatology, Schleswig-Holstein University Clinic, 24105 Kiel, Germany. echristophers@dermatology.uni-kiel.de

Clinics in Dermatology
|November 21, 2007
PubMed
Summary
This summary is machine-generated.

Psoriasis patients frequently develop associated disorders like psoriatic arthritis and metabolic syndrome due to overlapping inflammatory pathways. These comorbidities, often linked to chronic inflammation, manifest years after psoriasis onset, particularly in severe cases.

Related Experiment Videos

Last Updated: Jul 10, 2026

Measuring Psoriasis Severity at Home
02:28

Measuring Psoriasis Severity at Home

Published on: March 1, 2024

Area of Science:

  • Immunology
  • Dermatology
  • Epidemiology

Background:

  • Psoriasis is increasingly recognized as a systemic inflammatory disease.
  • Epidemiological studies reveal a higher incidence of comorbidities in psoriasis patients than expected.
  • These associated conditions include psoriatic arthritis, pustular diseases, Crohn disease, and metabolic syndrome, leading to atherosclerosis and coronary heart disease.

Purpose of the Study:

  • To explore the overlapping pathogenic pathways between psoriasis and its associated comorbidities.
  • To understand the role of chronic inflammation in the development of these linked disorders.
  • To investigate the immunologic mechanisms underlying psoriasis comorbidities.

Main Methods:

  • Review of epidemiological data on psoriasis comorbidities.
  • Analysis of biochemical and immunologic observations.
  • Investigation of inflammatory pathways, including cytokine secretion (e.g., tumor necrosis factor alpha).

Main Results:

  • Comorbidities often manifest years after psoriasis onset and are more prevalent in severe disease.
  • Persistent low-grade inflammation and proinflammatory cytokines contribute to insulin resistance and metabolic syndrome.
  • Overlapping pathogenic pathways link psoriasis to its diverse comorbidities, involving innate immune mechanisms.

Conclusions:

  • Psoriasis is associated with a spectrum of comorbidities driven by shared inflammatory processes.
  • Chronic inflammation is a key factor in the pathogenesis of psoriasis and its related conditions.
  • Understanding these links is crucial for comprehensive patient management and targeted therapies.