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Training locomotor networks.

V Reggie Edgerton1, Grégoire Courtine, Yury P Gerasimenko

  • 1Department of Physiological Science, University of California, Los Angeles, Los Angeles, CA 90095, USA. vre@ucla.edu

Brain Research Reviews
|November 21, 2007
PubMed
Summary
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Restoring weight-bearing stepping in spinal rats requires specific proprioceptive inputs and modulated spinal cord excitability. Pharmacological, electrical, or training-based methods can achieve this critical "physiological state" for sensory control of locomotion.

Area of Science:

  • Neuroscience
  • Motor Control
  • Spinal Cord Injury Research

Background:

  • Regaining weight-bearing stepping ability after spinal cord injury is a significant challenge.
  • Spinal cord circuits intrinsically generate stepping patterns, but require modulation for function.

Purpose of the Study:

  • To investigate methods for modulating spinal cord excitability to restore stepping in complete spinal rats.
  • To demonstrate sensory control of stepping and standing after spinal cord injury.

Main Methods:

  • Experiments conducted on adult rats with complete spinal cord transection.
  • Utilized pharmacological modulation, epidural electrical stimulation, and use-dependent training (stepping/standing).
  • Assessed the impact of these interventions on spinal circuitry excitability and proprioceptive input control.

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Main Results:

  • Specific proprioceptive inputs are crucial for weight-bearing stepping.
  • Spinal circuitry must be modulated to a critical excitability level for sensorimotor pathways to function.
  • Pharmacological, electrical, and training interventions successfully modulated spinal excitability.
  • Proprioceptive input effectively controlled stepping dynamics across various conditions after modulation.

Conclusions:

  • Modulating spinal cord circuitry to a critical window of excitability is essential for sensory control of stepping post-injury.
  • These findings offer insights into motor pattern formation and inform rehabilitation strategies for human spinal cord injuries.