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Related Concept Videos

Replication in Eukaryotes02:31

Replication in Eukaryotes

Overview
Replication in Eukaryotes02:31

Replication in Eukaryotes

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Proteins: From Genes to Degradation02:11

Proteins: From Genes to Degradation

Within a biological system, the DNA encodes the RNA, and the nucleotide sequence in the RNA further defines the amino acid sequence in the protein. This is referred to as “The Central Dogma of Molecular Biology” - a term coined by Francis Crick.  Central dogma is a firm principle in biology that defines the flow of genetic information within any life form. The two fundamental steps in central dogma are - transcription and translation.
Transcription is the synthesis of RNA molecules by RNA...
Protein Folding Quality Check in the RER01:29

Protein Folding Quality Check in the RER

ER is the primary site for the maturation and folding of soluble and transmembrane secretory proteins. The calnexin cycle is a specific chaperone system that folds and assesses the confirmation of N-glycosylated proteins before they can exit the ER lumen. The primary players of this quality check pipeline are the lectins, ER-resident chaperones, and a glucosyl transferase enzyme. In case the calnexin system in the lumen fails to salvage a misfolded protein, it is transported to the cytoplasm...
Replication in Eukaryotes01:29

Replication in Eukaryotes

In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
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Replication in Eukaryotes01:29

Replication in Eukaryotes

In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
Many Proteins Orchestrate Replication at the Origin
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Related Experiment Video

Updated: Jul 6, 2026

Assessment of DNA Contamination in RNA Samples Based on Ribosomal DNA
13:16

Assessment of DNA Contamination in RNA Samples Based on Ribosomal DNA

Published on: January 22, 2018

RNA quality control in eukaryotes.

Meenakshi K Doma1, Roy Parker

  • 1Department of Molecular and Cellular Biology and Howard Hughes Medical Institute, University of Arizona, Tucson, AZ 85721, USA.

Cell
|November 21, 2007
PubMed
Summary

Eukaryotic cells use RNA quality-control systems to maintain a healthy transcriptome. These pathways degrade aberrant RNAs and regulate normal messenger RNAs (mRNAs), ensuring cellular function and evolution.

Area of Science:

  • Molecular Biology
  • Genetics
  • Cell Biology

Background:

  • Eukaryotic cells possess sophisticated RNA quality-control mechanisms.
  • These systems are crucial for transcriptome integrity and cellular function.
  • They prevent the accumulation of nonfunctional RNAs and regulate normal mRNAs.

Purpose of the Study:

  • To elucidate the mechanisms and significance of RNA quality-control systems in eukaryotic cells.
  • To understand how these systems shape the transcriptome.
  • To explore the role of RNA quality control in cellular evolution.

Main Methods:

  • Analysis of kinetic competition between RNA biogenesis/function and degradation pathways.
  • Identification of specific adaptor proteins involved in targeting aberrant RNAs.

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Rup (RNA-seq Usability Assessment Pipeline) - Quality Control for Bulk RNA-seq Experiments in Eukaryotes

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Last Updated: Jul 6, 2026

Assessment of DNA Contamination in RNA Samples Based on Ribosomal DNA
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Genome-wide Surveillance of Transcription Errors in Eukaryotic Organisms
09:30

Genome-wide Surveillance of Transcription Errors in Eukaryotic Organisms

Published on: September 13, 2018

Rup (RNA-seq Usability Assessment Pipeline) - Quality Control for Bulk RNA-seq Experiments in Eukaryotes
05:07

Rup (RNA-seq Usability Assessment Pipeline) - Quality Control for Bulk RNA-seq Experiments in Eukaryotes

Published on: November 7, 2025

  • Investigation of the coupling between mRNA biogenesis and function steps.

    • Main Results:

    • RNA quality-control systems are essential for preventing nonfunctional RNA accumulation.
    • These systems actively regulate normal messenger RNAs (mRNAs).
    • Aberrant RNAs, including viral and parasitic RNAs, are repressed by these pathways.

    Conclusions:

    • RNA quality control is a dynamic process involving kinetic competition and specific adaptors.
    • These systems are vital for maintaining transcriptome homeostasis.
    • RNA quality control contributes to cellular defense and potentially the evolution of new RNAs and proteins.