Related Experiment Video
Updated: Jul 10, 2026

A Porcine Heterotopic Heart Transplantation Protocol for Delivery of Therapeutics to a Cardiac Allograft
Published on: February 14, 2022
Current trends in cardiac transplantation
1Cardiac Intensive Care Unit and Heart Failure Special Care Unit, Cleveland Clinic, Cleveland, OH, USA. kleind@ccf.org
Insights
Cardiac transplantation is a leading treatment for advanced heart failure in patients under 65. Success is due to liberal selection, effective immunosuppression, and rejection management.
Area of Science:
- Cardiology
- Transplantation Medicine
Background:
- Cardiac transplantation is the primary therapy for advanced heart failure in patients under 65.
- It is indicated for symptomatic patients despite maximal medical therapy.
Purpose of the Study:
- To present the current status of cardiac transplantation.
- To review recipient and donor selection, surgical techniques, postoperative care, immunosuppression, and rejection management.
Main Methods:
- Review of current practices in cardiac transplantation.
- Analysis of recipient and donor selection criteria.
- Evaluation of immunosuppression and rejection management strategies.
Main Results:
- Cardiac transplantation success is attributed to liberal selection criteria, effective immunosuppression, and rejection management.
- Current protocols cover selection, surgery, postoperative care, and immunosuppression.
Conclusions:
- Cardiac transplantation is a well-established treatment for advanced heart failure.
- Ongoing challenges include organ allocation, but management strategies ensure success.
Abstract:
More than 30 years of experience in cardiac transplantation have resulted in cardiac transplantation being the primary therapeutic choice for patients under 65 years of age who have advanced heart failure and who remain symptomatic despite maximal medical therapy. The success and widespread use of cardiac transplantation is attributed to more liberal guidelines in recipient and donor selection, effective immunosuppressive therapy, close monitoring for rejection, and effective management of rejection. This article presents the current status of recipient and donor selection, surgical techniques, postoperative care, immunosuppression strategies, and rejection monitoring and management. Challenges associated with allocation of organs continue.
Related Concept Videos
Tissue Transplantation
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Cardiomyopathy V: Interprofessional Care
Kidney Transplant I: Introduction
Bone Marrow Sampling and Transplants
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...

