Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

84.2K
Overview
84.2K
The Tumor Microenvironment02:17

The Tumor Microenvironment

7.8K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
7.8K
Humoral Immune Responses01:36

Humoral Immune Responses

84.0K
Overview
84.0K
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

8.9K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
8.9K
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

2.1K
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
2.1K
Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

9.3K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
9.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unraveling the interplay of glycolysis, lactylation, and autophagy.

International review of cell and molecular biology·2026
Same author

Oxidative and Glycolytic Metabolism: Their Reciprocal Regulation and Dysregulation in Cancer.

Cells·2025
Same author

Topical TLR7 agonist and radiotherapy in patients with metastatic breast cancer.

Journal for immunotherapy of cancer·2025
Same author

A Non-Pharmacological Paradigm Captures the Complexity in the Mechanism of Action of Poliprotect Against Gastroesophageal Reflux Disease and Dyspepsia.

International journal of molecular sciences·2025
Same author

The role of glycolysis in tumorigenesis: From biological aspects to therapeutic opportunities.

Neoplasia (New York, N.Y.)·2024
Same author

The Role of Oxidative Metabolism in Tumorigenesis and Drug Resistance.

Discovery medicine·2024

Related Experiment Video

Updated: Feb 8, 2026

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments
07:46

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments

Published on: April 30, 2021

5.5K

Tumor microenvironment and the immune response.

Silvia Selleri1, Cristiano Rumio, Marianna Sabatino

  • 1Infectious Disease and Immunogenetics Section, Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.

Surgical Oncology Clinics of North America
|November 21, 2007
PubMed
Summary

High-quality clinical data is essential for cancer research breakthroughs. Future clinical investigations by surgical oncologists are crucial for validating cancer cell and immune response hypotheses.

More Related Videos

Visualization, Quantification, and Mapping of Immune Cell Populations in the Tumor Microenvironment
11:00

Visualization, Quantification, and Mapping of Immune Cell Populations in the Tumor Microenvironment

Published on: March 25, 2020

17.9K
Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors
08:32

Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors

Published on: June 7, 2018

10.4K

Related Experiment Videos

Last Updated: Feb 8, 2026

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments
07:46

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments

Published on: April 30, 2021

5.5K
Visualization, Quantification, and Mapping of Immune Cell Populations in the Tumor Microenvironment
11:00

Visualization, Quantification, and Mapping of Immune Cell Populations in the Tumor Microenvironment

Published on: March 25, 2020

17.9K
Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors
08:32

Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors

Published on: June 7, 2018

10.4K

Area of Science:

  • Oncology
  • Immunology
  • Translational Research

Background:

  • Scientific conclusions require robust clinical data, including accurate follow-up and high-quality sample collection.
  • Theoretical assumptions in cancer research often lack clinical validation.
  • Understanding the interplay between cancer cells and the host immune response is critical for therapeutic advancements.

Purpose of the Study:

  • To discuss the current understanding of the cancer cell-host immune response relationship.
  • To highlight the necessity of clinical investigations for validating scientific hypotheses.
  • To emphasize the role of surgical oncologists in bridging bench-side research and clinical application.

Main Methods:

  • Review and discussion of existing literature on cancer immunology and clinical data requirements.
  • Analysis of the limitations imposed by inadequate clinical information on research validity.
  • Emphasis on the prospective role of clinical studies in hypothesis assessment.

Main Results:

  • Inadequate clinical information, sample quality, and follow-up compromise the reliability of scientific conclusions.
  • Theoretical hypotheses regarding cancer biology and immunology remain unproven without clinical validation.
  • The gap between bench-side discoveries and clinical breakthroughs persists due to data limitations.

Conclusions:

  • Future clinical investigations are indispensable for validating cancer cell-host immune response hypotheses.
  • Surgical oncologists are pivotal in leading clinical studies to bridge basic science and patient care.
  • High-quality clinical data collection and follow-up are paramount for advancing cancer treatment strategies.