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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...

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Related Experiment Video

Updated: Jul 10, 2026

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports
07:44

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports

Published on: November 28, 2019

Tumor microenvironment and immune escape.

Soldano Ferrone1, Theresa L Whiteside

  • 1Hillman Cancer Center, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213-1863, USA. ferrones@upmc.edu

Surgical Oncology Clinics of North America
|November 21, 2007
PubMed
Summary

Tumor cells evade immune destruction through various escape mechanisms. These involve changes in tumor cells and T-cells within the tumor microenvironment, impacting anti-tumor responses.

Area of Science:

  • Immunology
  • Cancer Biology
  • Oncology

Background:

  • Tumor cells develop strategies to evade immune surveillance and destruction.
  • T-cell-mediated immunity is a critical component of the anti-tumor response.
  • The tumor microenvironment plays a significant role in modulating immune responses against cancer.

Purpose of the Study:

  • To elucidate the diverse mechanisms employed by tumor cells to escape T-cell-mediated elimination.
  • To examine how alterations in tumor cells and T-cells within the tumor microenvironment contribute to immune evasion.
  • To highlight the impact of regulatory T-cells and T-cell apoptosis on anti-tumor immunity.

Main Methods:

  • Review of existing literature on tumor immune evasion.
  • Analysis of molecular and cellular changes in tumor cells and T-lymphocytes.

More Related Videos

Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors
08:32

Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors

Published on: June 7, 2018

Related Experiment Videos

Last Updated: Jul 10, 2026

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports
07:44

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports

Published on: November 28, 2019

Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors
08:32

Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors

Published on: June 7, 2018

  • Discussion of the tumor microenvironment's influence on immune interactions.

    • Main Results:

    • Tumor cells utilize multiple strategies to avoid recognition and destruction by cytotoxic T-lymphocytes.
    • Regulatory T-cells and T-cell apoptosis can suppress tumor antigen-specific cytotoxic T-lymphocyte responses.
    • Altered expression of histocompatibility antigens on tumor cells affects interactions with immune cells.

    Conclusions:

    • Understanding tumor immune escape mechanisms is crucial for developing effective cancer immunotherapies.
    • Targeting these escape pathways could enhance T-cell-mediated anti-tumor activity.
    • Modulating the tumor microenvironment and antigen presentation holds therapeutic potential.