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Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation
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T cell receptor and CD3 antibody crossreactivity opens new research and veterinary medicine opportunities

William J Karpus1

  • 1Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. w-karpus@northwestern.edu

Cytometry. Part a : the Journal of the International Society for Analytical Cytology
|November 21, 2007
PubMed
Abstract

No abstract available in PubMed .

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Cross-reactivity00:42

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Overview
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...

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