Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Genetic enhancers.

Robert K Herman1, John Yochem

  • 1Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA. bob-h@umn.edu

Wormbook : the Online Review of C. Elegans Biology
|November 21, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MIP-MAP: High-Throughput Mapping of <i>Caenorhabditis elegans</i> Temperature-Sensitive Mutants via Molecular Inversion Probes.

Genetics·2017
Same author

High-Throughput Cloning of Temperature-Sensitive Caenorhabditis elegans Mutants with Adult Syncytial Germline Membrane Architecture Defects.

G3 (Bethesda, Md.)·2015
Same author

FBN-1, a fibrillin-related protein, is required for resistance of the epidermis to mechanical deformation during C. elegans embryogenesis.

eLife·2015
Same author

C. elegans NIMA-related kinases NEKL-2 and NEKL-3 are required for the completion of molting.

Developmental biology·2014
Same author

A novel nondevelopmental role of the sax-7/L1CAM cell adhesion molecule in synaptic regulation in Caenorhabditis elegans.

Genetics·2014
Same author

Analysis of PHA-1 reveals a limited role in pharyngeal development and novel functions in other tissues.

Genetics·2014
Same journal

Caenorhabditis nomenclature.

WormBook : the online review of C. elegans biology·2018
Same journal

Tubulins in C. elegans.

WormBook : the online review of C. elegans biology·2018
Same journal

History of research on C. elegans and other free-living nematodes as model organisms.

WormBook : the online review of C. elegans biology·2017
Same journal

Development, structure, and maintenance of C. elegans body wall muscle.

WormBook : the online review of C. elegans biology·2016
Same journal

Working with dauer larvae.

WormBook : the online review of C. elegans biology·2016
Same journal

Small GTPases.

WormBook : the online review of C. elegans biology·2016
See all related articles

Genetic enhancers are mutations that amplify the effects of other gene mutations. Identifying these enhancers helps discover interacting genes, including those with redundant functions, using methods like RNA interference screening.

Area of Science:

  • Genetics
  • Molecular Biology
  • Developmental Biology

Background:

  • Genetic enhancers are mutations that intensify phenotypes caused by mutations in other genes.
  • The combined phenotype of double mutants is more severe than the sum of individual mutant phenotypes.
  • Identifying enhancers reveals interacting genes, including those with redundant functions.

Purpose of the Study:

  • To review the utility of dominant and recessive genetic enhancers.
  • To highlight methods for identifying interacting genes through enhancer screening.
  • To discuss the application of genome-wide RNA interference screening for recessive enhancer identification.

Main Methods:

  • Review of dominant and recessive enhancer examples in Caenorhabditis elegans.

Related Experiment Videos

  • Analysis of gene interactions revealed by enhancers, including homologous and nonhomologous interactions.
  • Application of genome-wide screening using RNA interference for identifying recessive enhancers.

    • Main Results:

    • Dominant and recessive enhancers provide insights into gene interactions.
    • Enhancer identification can uncover genes with redundant functions.
    • Genome-wide RNA interference screening is a powerful tool for discovering recessive enhancers.

    Conclusions:

    • Genetic enhancers are valuable tools for dissecting gene function and interactions.
    • The study of enhancers, particularly through advanced screening methods, advances our understanding of genetic pathways.
    • Identifying interacting genes, whether homologous or nonhomologous, is crucial for a comprehensive understanding of biological systems.