Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

American Trypanosomiasis01:22

American Trypanosomiasis

Chagas disease, or American trypanosomiasis, is a vector-borne parasitic infection caused by Trypanosoma cruzi, a flagellated protozoan (kinetoplastid) of the family Trypanosomatidae. The disease is endemic in Latin America, although cases are increasingly reported worldwide due to human migration. Transmission most commonly occurs when feces of infected triatomine bugs contaminate bite wounds or mucosal surfaces; additional routes include congenital, transfusional, transplant-related, and oral...
Mitosis and Cytokinesis01:35

Mitosis and Cytokinesis

In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
Mitosis and Cytokinesis02:03

Mitosis and Cytokinesis

In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
Mitosis And Cytokinesis01:35

Mitosis And Cytokinesis

In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
Mitosis and Cytokinesis02:03

Mitosis and Cytokinesis

In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
Centrioles and Centrosomes01:13

Centrioles and Centrosomes

Most animal cells comprise a pair of centrioles together called a centrosome. The cell duplicates its centrosome and contains two centrosomes side-by-side, which begin to move apart during the prophase. As the centrosomes migrate to two different sides of the cell, microtubules start extending from each centrosome toward the other end. The mitotic spindle is composed of the centrosomes and their emerging microtubules.
Near the end of the prophase, also called late prophase or "prometaphase,"...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cathepsin G and neutrophil elastase control Leishmania infantum parasitism through TLRs-dependent induction of IFN-α and TNF-α.

Communications biology·2026
Same author

Chemical genetics reveals Leishmania KKT2 and CRK9 kinase activity is required for cell cycle progression.

PLoS pathogens·2026
Same author

CRISPR-Cas9 precision editing of kinetochore protein phosphosite codons in <i>Leishmania mexicana</i>.

Frontiers in cellular and infection microbiology·2026
Same author

Subcellular proteomics reveals a blueprint for endosymbiont integration in trypanosomatid Angomonas deanei.

Nature communications·2026
Same author

High-Throughput Cell Cycle and Morphological Analysis of Leishmania mexicana and Other Kinetoplastids.

Methods in molecular biology (Clifton, N.J.)·2026
Same author

Discovery and Characterization of Cell-Permeable Inhibitors of <i>Leishmania mexicana</i> CLK1 Using an In-Cell Target Engagement Assay.

ACS infectious diseases·2025

Related Experiment Video

Updated: Jul 10, 2026

Ultrastructural Expansion Microscopy in Three In Vitro Life Cycle Stages of Trypanosoma cruzi
09:45

Ultrastructural Expansion Microscopy in Three In Vitro Life Cycle Stages of Trypanosoma cruzi

Published on: May 12, 2023

Cytokinesis in trypanosomatids.

Tansy C Hammarton1, Séverine Monnerat, Jeremy C Mottram

  • 1Wellcome Centre for Molecular Parasitology, University of Glasgow, 120 University Place, Glasgow G12 8TA, United Kingdom.

Current Opinion in Microbiology
|November 21, 2007
PubMed
Summary

Cytokinesis, or cell division, is complex in trypanosomatids due to single-copy organelle replication. This review examines factors affecting cell division in Trypanosoma brucei.

Area of Science:

  • Cell Biology
  • Parasitology
  • Molecular Biology

Background:

  • Cytokinesis involves the division of cytoplasm to form two daughter cells.
  • Trypanosomatids present unique challenges in cell division due to the replication of single-copy organelles like the nucleus, kinetoplast, Golgi apparatus, and flagellum.
  • Understanding cytokinesis regulation is crucial for parasitic protozoa like Trypanosoma brucei.

Purpose of the Study:

  • To review the intricate process of cytokinesis in trypanosomatids.
  • To identify regulators involved in the initiation, furrow ingression, and abscission stages of cell division.
  • To discuss the challenges in studying cytokinesis due to its sensitivity to perturbation in trypanosomatids.

Main Methods:

  • Review of existing literature on trypanosomatid cell division.

More Related Videos

Purification of Extracellular Trypanosomes, Including African, from Blood by Anion-Exchangers (Diethylaminoethyl-cellulose Columns)
14:26

Purification of Extracellular Trypanosomes, Including African, from Blood by Anion-Exchangers (Diethylaminoethyl-cellulose Columns)

Published on: April 6, 2019

Spatiotemporal Analysis of Cytokinetic Events in Fission Yeast
11:19

Spatiotemporal Analysis of Cytokinetic Events in Fission Yeast

Published on: February 20, 2017

Related Experiment Videos

Last Updated: Jul 10, 2026

Ultrastructural Expansion Microscopy in Three In Vitro Life Cycle Stages of Trypanosoma cruzi
09:45

Ultrastructural Expansion Microscopy in Three In Vitro Life Cycle Stages of Trypanosoma cruzi

Published on: May 12, 2023

Purification of Extracellular Trypanosomes, Including African, from Blood by Anion-Exchangers (Diethylaminoethyl-cellulose Columns)
14:26

Purification of Extracellular Trypanosomes, Including African, from Blood by Anion-Exchangers (Diethylaminoethyl-cellulose Columns)

Published on: April 6, 2019

Spatiotemporal Analysis of Cytokinetic Events in Fission Yeast
11:19

Spatiotemporal Analysis of Cytokinetic Events in Fission Yeast

Published on: February 20, 2017

  • Focus on Trypanosoma brucei as a model organism.
  • Analysis of direct and indirect effects on the cytokinesis process.

    • Main Results:

    • Cytokinesis in trypanosomatids is a complex process requiring coordinated replication and segregation of multiple organelles.
    • Perturbing gene function easily disrupts cell division, leading to aberrant cell morphologies.
    • Identifying specific regulatory factors is challenging due to the sensitivity of the division process.

    Conclusions:

    • The study highlights the complexity of cytokinesis in trypanosomatids, particularly in Trypanosoma brucei.
    • Further research is needed to fully elucidate the regulatory mechanisms governing cell division in these organisms.
    • Understanding these mechanisms could offer targets for therapeutic interventions against trypanosome infections.