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Flow Cytometry-based Assay for the Monitoring of NK Cell Functions
Published on: October 30, 2016
Immunotherapies for Hodgkin's lymphoma
Yvette L Kasamon1, Richard F Ambinder
1Division of Hematologic Malignancies, Johns Hopkins Medical Institutions, Baltimore, MD, USA. ykasamo1@jhmi.edu
Critical Reviews in Oncology/Hematology
|November 21, 2007
Summary
Hodgkin's lymphoma employs immune evasion tactics, crucial for developing new immunotherapies. This review covers adoptive immunotherapy and monoclonal antibodies targeting CD30 and CD20.
Area of Science:
- Oncology
- Immunology
- Pathobiology
Background:
- Hodgkin's lymphoma exhibits complex immune evasion mechanisms.
- Understanding these strategies is vital for effective treatment development.
Purpose of the Study:
- To review clinical experiences with immunotherapies for Hodgkin's lymphoma.
- To highlight the role of immune evasion in treatment resistance.
Main Methods:
- Review of clinical data on adoptive immunotherapy for Epstein-Barr virus positive tumors.
- Analysis of studies involving monoclonal antibodies targeting CD30, CD20, and other antigens.
Main Results:
- Clinical data on adoptive immunotherapy for EBV-positive Hodgkin's lymphoma were examined.
- Efficacy and challenges of CD30- and CD20-targeted monoclonal antibody therapies were assessed.
Conclusions:
- Immune evasion is a key factor in Hodgkin's lymphoma pathobiology.
- Consideration of these evasion strategies is essential for advancing immunotherapy for Hodgkin's lymphoma.
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