Related Experiment Video
Updated: Jul 10, 2026

Heterogeneity Mapping of Protein Expression in Tumors using Quantitative Immunofluorescence
Published on: October 25, 2011
Molecular heterogeneity of colorectal cancer: Implications for cancer control
1Department of Cellular Pathology, St. Mark's Hospital, Watford Road, Harrow, Middx HA1 3UJ, UK. jeremy.jass@nwlh.nhs.uk
Abstract:
Colorectal cancer (CRC) is a multi-pathway disease. A molecular approach to the classification of CRC utilises: (1) the type of genetic instability, specifically microsatellite instability (MSI) versus stable (MSS), and (2) the presence of DNA methylation or the CpG island methylator phenotype (CIMP). The MSS/CIMP-neg subset evolves through the classical adenoma-carcinoma sequence while the MSI/CIMP-pos and MSS/CIMP-pos subsets evolve through the recently recognised 'serrated pathway'. This review will show that the existence of two or more independent pathways to CRC is relevant to cancer prevention. In particular, new strategies for detecting and managing sessile serrated polyps will need to be developed and evaluated.
Related Concept Videos
Cancer
Cancer Stem Cells and Tumor Maintenance
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancers Originate from Somatic Mutations in a Single Cell
Cancers Originate from Somatic Mutations in a Single Cell
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
Treatment Resistant Cancers
