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Tissue factor and PAR signaling in tumor progression
1Department of Immunology, Scripps Research Institute, La Jolla, CA, USA. ruf@scripps.edu
Thrombosis Research
|November 21, 2007
Summary
Tumor cells interact with their environment through tissue factor (TF). The hemostatic system influences tumor growth, and targeting TF offers potential therapeutic strategies for cancer progression.
Area of Science:
- Oncology
- Hemostasis
- Tumor Microenvironment
Background:
- Tumor progression involves complex interactions between tumor cells and the host microenvironment.
- Tumor cells release factors like procoagulant microparticles, cytokines, and growth factors, initiating tissue factor (TF)-dependent communication.
- The host's hemostatic system plays a regulatory role in tumor growth and angiogenesis.
Purpose of the Study:
- To elucidate the role of tissue factor (TF) in tumor progression and metastasis.
- To identify potential therapeutic strategies targeting the TF pathway in cancer.
Main Methods:
- Utilized experimental models of spontaneous tumor development.
- Employed experimental models of transplanted tumor development and metastasis.
- Investigated the crosstalk between tumor cells and the tumor microenvironment.
Main Results:
- Demonstrated TF-dependent crosstalk initiated by tumor cells.
- Showcased the influence of the hemostatic system on tumor growth and angiogenesis.
- Delineated the role of TF in tumor progression and metastasis.
Conclusions:
- Tissue factor (TF) is a critical mediator in tumor development and progression.
- Targeting the TF pathway presents a promising therapeutic avenue for cancer treatment.
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