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Updated: Jul 10, 2026
08:49
A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
Epidermal manifestations of internal malignancy
Rachael L Moore1, Theresa S Devere
1Department of Dermatology, Oregon Health and Science University, 3303 SW Bond Avenue, CH16D, Portland, OR 97239, USA.
Dermatologic Clinics
|November 21, 2007
Summary
This article reviews paraneoplastic syndromes affecting the epidermis. These skin conditions are associated with internal cancers and include malignant acanthosis nigricans and Leser-Trélat sign.
Area of Science:
- Dermatology
- Oncology
Background:
- Paraneoplastic syndromes are systemic disorders linked to malignancies.
- Cutaneous manifestations can be early indicators of underlying cancer.
- Epidermal changes are a specific subset of these dermatologic signs.
Purpose of the Study:
- To discuss paraneoplastic syndromes with epidermal findings.
- To highlight specific dermatologic conditions associated with cancer.
- To review diagnostic and clinical correlations.
Main Methods:
- Literature review of paraneoplastic syndromes.
- Focus on conditions with epidermal localization.
- Discussion of key clinical features and associations.
Main Results:
- Several epidermal paraneoplastic syndromes are presented.
- Examples include malignant acanthosis nigricans, Leser-Trélat sign, tripe palms, palmoplantar keratodermas, Bazex syndrome, and acquired ichthyosis.
- Correlation between skin findings and malignancy is generally observed.
Conclusions:
- Epidermal paraneoplastic syndromes are important markers of internal malignancy.
- Recognition of these skin findings aids in early cancer diagnosis.
- Further research into pathogenesis and management is warranted.
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